Review: Recent advances in one-pot multi-component catalytic synthesis of amidoalkyl naphthols
Authors
Abstract:
Amidoalkyl-2-naphthols as synthetic intermediates play an important role in medicinal chemistry due to their remarkable biological and many pharmacological properties. Owing to the versatile biological activities, industrial and synthetic applications of these compounds, introduction of an alternative methodology is urgent in synthetic organic chemistry. Low yield and harsh reaction conditions promoted the researchers for the development of novel green catalysts for the synthesis of amidoalkyl-naphthols. Therefore in the present review, we deal with green catalytic synthesis of amidoalkyl-naphthols. The main purpose of this review is to present a survey of the literature on various heterogenous and homogenous catalysts used for the synthesis of amidoalkyl-naphthols alongwith mechanism of reaction since synthesis of such compounds have not been previously reviewed.
similar resources
review: recent advances in one-pot multi-component catalytic synthesis of amidoalkyl naphthols
amidoalkyl-2-naphthols as synthetic intermediates play an important role in medicinal chemistry due to their remarkable biological and many pharmacological properties. owing to the versatile biological activities, industrial and synthetic applications of these compounds, introduction of an alternative methodology is urgent in synthetic organic chemistry. low yield and harsh reaction conditions ...
full textOne-Pot Multi-Component Synthesis of Amidoalkyl Naphthols with Potassium Hydrogen Sulfate as Catalyst under Solvent-Free Condition
One-pot multicomponent condensation of β-naphthol, aromatic aldehydes, acetamide or urea in the presence of potassium hydrogen sulfate was carried out under solvent-free condition to afford amidoalkyl naphthols in 83%~96% yields.
full textOne-Pot Multi-Component Synthesis of Dihydropyrimidinones via Biginelli Condensation
Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...
full textGraphite-supported perchloric acid (HClO4-C): an efficient and recyclable heterogeneous catalyst for the one-pot synthesis of amidoalkyl naphthols.
An efficient and direct protocol for the preparation of amidoalkylnaphthols employing a multi-component, one-pot condensation reaction of 2-naphthol, aromatic aldehydes and acetamide or benzamide in the presence of graphite supported perchloric acid under solvent-free conditions is described. The thermal solvent-free procedure offers advantages such as simple work-up, shorter reaction times and...
full textLactic acid, as an efficient catalyst for the one-pot three-component synthesis of 1-amidoalkyl-2-naphthols under thermal solvent-free conditions
For the first time lactic acid was applied as an efficient and green catalyst for the one-pot three-component synthesis of amidoalkyl naphthols via the condensation between arylaldehydes, 2-naphthol and amides or urea under thermal solvent-free conditions in good to excellent yields. We have demonestrated a mild and efficient eco-friendly tandem synthesis of amidoalkyl naphthols using lactic ac...
full textMy Resources
Journal title
volume 5 issue 3
pages 187- 206
publication date 2015-09-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023